Use of Silver Sulfadiazine cream and its restrictions

Silver Sulfadiazine cream is mainly used as antibacterial medication for topical burns and chemical burns. The main aim of the medication is to prevent the spread and development of array of bacteria and yeast on the damaged area of the skin. There are many companies manufacturing the cream and has attained different names for the same. It is usually available in 1% in the cream and aqueous solutions. A complete research on the medication has proved that, long use of the cream increases the healing time and hence is not recommended by Cochrane review.

Speaking of the use of Silver Sulfadiazine cream, it is mainly a cream prescribed by doctor for burns and severe skin damages. Known for its topical usage, the medication will be available for sale only medical stores and upon submission of a valid prescription. Coming to its pharmacokinetic data, the product contains 1% of silver and 10% of sulfadiazine. Due to this, there is a high protein binding for silver, making it the most important factor for the total composition. Side effects may include hypersensitivity and reactions like erythema multiforme and rashes. The percentage is about 0.1-1% and depends on the individual skin texture.

When a person applying Silver Sulfadiazine cream exposes the affected area to ultraviolet, one can observe argyria (discoloration) due to incorporation of silver ions. Hence, the use of cream is very much limited depending on the amount of burns and damage to the skin. Penetration into body through the skin is not possible for the cream as it is poorly soluble and only enters the body when the application is on large areas of burns. This might create a problem and may even lead to side effects. Any changes should immediately be noted to the doctor to stop the spread of the cream in the body.